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The mechanisms underlying de novo insertion/deletion (indel) genesis, such as polymerase slippage, have been hypothesized but not well characterized in the human genome. We implemented two methodological improvements, which were leveraged to dissect indel mutagenesis. We assigned de novo variants to parent‐of‐origin (i.e., phasing) with low‐coverage long‐read whole‐genome sequencing, achieving better...