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In this study we longitudinally investigated the rate of microstructural alterations in the occipital cortex in different stages of Huntington’s disease (HD) by applying an automated atlas-based approach to diffusion MRI data. Twenty-two premanifest (preHD), 10 early manifest HD (early HD) and 24 healthy control subjects completed baseline and two year follow-up scans. The preHD group was stratified...
ObjectivesTo investigate both cross‐sectional and time‐related changes of striatal and whole‐brain microstructural properties in different stages of Huntington's disease (HD) using diffusion tensor imaging.
Experimental designFrom the TRACK‐HD study, premanifest gene carriers (preHD), early manifest HD and controls were scanned at baseline and 2‐year follow‐up. Stratification of the preHD group into...
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