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Identification of Mononucleotides
In article number 2102567, Steven A. Soper, Sunggook Park, and co‐workers develop a novel polymer nanofluidic sensor consisting of a nanochannel column and two sub‐10 nm in‐plane pores formed in polymer substrate via nanoimprint lithography. This nanosensor demonstrates label‐free detection and identification of dNMPs, the building block of DNAs, via their time‐of‐flight...
Nanoscale electrophoresis allows for unique separations of single molecules, such as DNA/RNA nucleobases, and thus has the potential to be used as single molecular sensors for exonuclease sequencing. For this to be envisioned, label‐free detection of the nucleotides to determine their electrophoretic mobility (i.e., time‐of‐flight, TOF) for highly accurate identification must be realized. Here, for...
Electrophoresis or electrochromatography carried out in nanometer columns (width and depth) offers some attractive benefits compared to microscale columns. These advantages include unique separation mechanisms that are scale dependent, fast separation times, and simpler workflow due to the lack of a need for column packing and/or wall coatings to create a stationary phase. We report the use of thermoplastics,...
DOI: 10.1002/elps.202000109
The front cover picture shows a single‐stranded DNA molecule moving electrokinetically through a nanochannel (100 × 100 nm, width × depth) made from the plastic poly(methylmetharcylate), PMMA, and detected using laser‐induced fluorescence. The separation, which is scale‐dependent, is based on a combination of electrophoresis and chromatography – open tubular nano‐electrochromatography...
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