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Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow‐cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we asked whether such slow‐cycling cells could be eliminated by co‐treatment with the...
DCs develop from multipotent progenitors (MPPs), which commit into DC‐restricted common dendritic cell progenitors (CDPs). CDPs further differentiate into classical DCs (cDCs) and plasmacytoid DCs (pDCs). Here, we studied the impact of histone acetylation on DC development in C57BL/6 mice by interfering with histone acetylation and deacetylation, employing histone deacetylase (HDAC) inhibitors. We...
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