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Whether respiratory syncytial virus (RSV) induces severe infantile pulmonary disease may depend on viral strain and expression of types I and III interferons (IFNs). These IFNs impact disease severity by inducing expression of many anti-viral IFN-stimulated genes (ISGs). To investigate the impact of RSV strain on IFN and ISG expression, we stimulated human monocyte-derived DCs (MDDCs) with either...
Human type I interferons (IFNs) include IFN‐β and 12 subtypes of IFN‐α. During viral infection, infiltrating memory CD4+T cells are exposed to IFNs, but their impact on memory T‐cell function is poorly understood. To address this, we pretreated PBMCs with different IFNs for 16 h before stimulation with Staphylococcus aureus enterotoxin B and measured cytokine expression by flow cytometry. IFN‐α8 and...
Type I interferons (IFNs) are expressed by all nucleated cells in response to viral pathogens and modulate innate and adaptive immune responses by stimulating expression of subsets of interferon stimulated genes (ISGs). There are over 1000 ISGs, including more than 60 that are transcription factors (TFs). Type I IFNs share the same receptor complex and are comprised of multiple species, including...
Interferons play a key role in the innate immune response to viral infection. In this study, we determined which IFN genes are expressed by primary human bronchial epithelial (HBE) cells following infection with respiratory syncytial virus (RSV) strain A2. Infection of HBE cells with RSV induced co-expression of the IFN-lambda genes (IFNL1, IFNL2 andIFNL3) in a dose- and time-dependent manner. It...
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