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To circumvent the limitations of current antidepressants, WJ‐14, a novel N‐methyl‐d‐aspartate receptor antagonist, was synthesized and demonstrated to have remarkable efficiency in the treatment of depression. To illustrate the pharmacokinetics, absolute bioavailability, and tissue distribution of WJ‐14 in rats, a rapid and sensitive liquid chromatography–tandem mass spectrometry–based analytical...
Chronic diabetic wounds remain a worldwide challenge for both the clinic and research. Given the vicious circle of oxidative stress and inflammatory response as well as the impaired angiogenesis of the diabetic wound tissues, the wound healing process is disturbed and poorly responds to the current treatments. In this work, a nickel‐based metal‐organic framework (MOF, Ni‐HHTP) with excellent antioxidant...
Objective
The study's objective was to explore whether early time‐restricted eating (eTRE) and late time‐restricted eating (lTRE) have different impacts on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease (NAFLD).
Methods
This is an 8‐week, randomized, parallel‐arm, open‐label trial. Forty eligible patients were randomly assigned to eTRE (eating between...
Objectives
To evaluate the left ventricular energy loss (EL), energy loss reserve (EL‐r), and energy loss reserve rate in patients with mild coronary artery stenosis by using vector flow mapping (VFM) combined with exercise stress echocardiography.
Methods
A total of 34 patients (case group) with mild coronary artery stenosis and 36 sex and age matched patients (control group) without coronary...