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Cover illustration: The front cover image is based on the Original Article Drosophila Pericentrin‐like protein promotes the formation of primordial germ cells by Dorothy Lerit and Junnan Fang, https://doi.org/10.1002/dvg.23347.
Primordial germ cells (PGCs) are the precursors to the adult germline stem cells that are set aside early during embryogenesis and specified through the inheritance of the germ plasm, which contains the mRNAs and proteins that function as the germline fate determinants. In Drosophila melanogaster, formation of the PGCs requires the microtubule and actin cytoskeletal networks to actively segregate...
The H3 histone variant CENP-A is an epigenetic marker critical for the centromere identity and function. However, the precise regulation of the spatiotemporal deposition and propagation of CENP-A at centromeres during the cell cycle is still poorly understood. Here, we show that CENP-A is phosphorylated at Ser68 during early mitosis by Cdk1. Our results demonstrate that phosphorylation of Ser68 eliminates...
Acyl‐CoA dehydrogenase [acyl‐CoA:(acceptor) 2,3‐oxidoreductase; EC 1.3.99.3] catalyzes the first reaction step in mitochondrial fatty‐acid β‐oxidation. Here, the very‐long‐chain acyl‐CoA dehydrogenase from Caenorhabditis elegans (cVLCAD) has been cloned and overexpressed in Escherichia coli strain BL21 (DE3). Interestingly, unlike other very‐long‐chain acyl‐CoA dehydrogenases, cVLCAD was found to...
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