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In this study, we report the chemical synthesis, computational analysis, and anti‐virulent studies of five Vanillin‐based hybrids employing phytochemicals. Vanillin (V) is known to have substantial anti‐quorum sensing activity against the gram‐negative pathogen Pseudomonas aeruginosa. Therefore, with the aim to further enhance the potency of Vanillin, it was chemically conjugated via a triazole (T)...