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Langerhans cell sarcoma (LCS) and quintuple cancers are extremely rare. In this report, a case of quintuple cancers including LCS was described. An 80‐year‐old man had squamous cell carcinoma of the nasal skin, colon and rectum adenocarcinomas, and T‐cell/histiocyte‐rich large B‐cell lymphoma. As swelling of multiple submental lymph nodes was observed, fine‐needle aspiration was carried out. Many...