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Porphyromonas gulae, an animal‐derived periodontal pathogen, expresses several virulence factors, including fimbria, lipopolysaccharide (LPS) and proteases. We previously reported that its invasive efficiency was dependent on fimbriae types. In addition, P. gulae LPS increased inflammatory responses via toll‐like receptors. The present study was conducted to investigate the involvement of P. gulae...