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Proteins of the Leishmania hydrophilic acylated surface protein B (HASPB) family are only expressed in infective parasites (both extra‐ and intracellular stages) and, together with the peripheral membrane protein SHERP (small hydrophilic endoplasmic reticulum‐associated protein), are essential for parasite differentiation (metacyclogenesis) in the sand fly vector. HASPB is a ‘non‐classically’ secreted...