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Recent evidence has suggested that Srv2/CAP (cyclase‐associated protein) has two distinct functional roles in regulating actin turnover, with its N‐terminus enhancing cofilin‐mediated severing of actin filaments and its C‐terminus catalyzing actin monomer recycling. However, it has remained unclear to what degree these two activities are coordinated by being linked in one molecule, or whether they...
Cellular processes propelled by actin polymerization require rapid disassembly of filaments, and then efficient recycling of ADF/cofilin‐bound ADP‐actin monomers back to an assembly‐competent ATP‐bound state. How monomer recharging is regulated in vivo is still not well understood, but recent work suggests the involvement of the ubiquitous actin‐monomer binding protein Srv2/CAP. To better understand...
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