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Repository corticotrophin injection (RCI, H.P Acthar® gel) has been approved for use in the management of multiple autoimmune and inflammatory diseases for more than a half‐century, but its mechanism of action is not well understood. We used RNA‐Seq methods to define RCI‐regulated mRNAs in cultured human B cells under conditions of activation by interleukin (IL)‐4 and CD40 ligand. Following IL‐4/CD40L...