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Objectives
Proliferation of hepatocytes in vitro can be stimulated by growth factors such as epidermal growth factor (EGF), but the role of vasoactive intestinal peptide (VIP) remains unclear. We have investigated the effect of VIP on maintenance and proliferation of human hepatocytes.
Materials and methods
Human hepatocytes were isolated from liver specimens obtained from patients undergoing liver...
Background
Tryptase, the most abundant protease of the human mast cell, has been implicated as a key mediator of allergic inflammation that acts through activation of PAR2.
Objectives
To investigate the contribution of PAR2 in the pro‐inflammatory actions mediated by tryptase in a mice model.
Methods
We have injected recombinant human βII‐tryptase into the peritoneum of PAR2‐deficient and wild‐type...
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