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Background Expression of the CNDP2 gene is frequently up- or down-regulated in different types of human cancers. However, how the product of this gene is involved in cell growth and proliferation is poorly understood. Moreover, our knowledge of the functions of the CNDP2 orthologs in well-established model organisms is scarce. In particular, the function of the D. melanogaster ortholog of CNDP2, encoded...
Pioneering single gene study documents pre‐mRNA processing proteins participation in the cell‐cycle regulation of multi‐cellular animals (Andersen and Tapon, 2008, J Biol Chem 283: 31256–67). Whole‐genome RNAi screen in Drosophila tissue‐culture cell lines demonstrates that 17 genes involved in RNA‐processing are required for G2/M check‐point function (Kondo and Perrimon, 2011, Sci Signal 4: rs1)...
Morbidity and mortality in mice were observed upon administration of exogenous DNA following their pre-treatment with a cytostatic agent cyclophosphamide. Upon intraperitoneal injections, the fragments of exogenous DNA reached bone marrow cells. These cells were also found to internalize up to 1800kb of exogenous DNA ex vivo. The 18–24h time frame represents a final stage in the repair of DNA double-strand...
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