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In our search for new small molecules activating procaspase‐3, we have designed and synthesized a series of new acetohydrazides incorporating both 2‐oxoindoline and 4‐oxoquinazoline scaffolds. Biological evaluation showed that a number of these acetohydrazides were comparably or even more cytotoxic against three human cancer cell lines (SW620, colon cancer; PC‐3, prostate cancer; NCI−H23, lung cancer)...
In our search for novel small cytotoxic molecules potentially activating procaspase‐3, we have designed and synthesized a series of novel N′‐[(E)‐arylidene]‐2‐(2,3‐dihydro‐3‐oxo‐4H‐1,4‐benzoxazin‐4‐yl)acetohydrazides (5, 6). Biological evaluation revealed that seven compounds, including 5h, 5j, 5k, 5l, 5n, 6a, and 6b, exhibited moderate to strong cytotoxicity against three human cancer cell lines...
Offshore platforms work in complex and harsh environments, in addition to normal work load, environment loads, also threatened by accidental loads, such as the impact of ships. Major disaster caused by accidental loading will not only result in casualties and major economic losses, but also the surrounding coastal environment and marine ecosystem caused by pollution and destruction So it is essential...
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