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d-Serine is a non-proteinogenic amino acid that acts as a co-agonist of the NMDA receptors in the central nervous system. d-Serine is produced by human serine racemase (hSR), a homodimeric pyridoxal 5′-phosphate (PLP)-dependent enzyme that also catalyzes the physiologically relevant β-elimination of both l- and d-serine to pyruvate and ammonia. After improving the protein purification yield and stability,...
The N‐methyl d‐aspartate (NMDA) receptors play a key role in excitatory neurotransmission, and control learning, memory and synaptic plasticity. Their activity is modulated by the agonist glutamate and by the co‐agonists d‐serine and glycine. In the human brain, d‐serine is synthesized from l‐serine by the dimeric pyridoxal 5′‐phosphate‐dependent enzyme serine racemase, which also degrades l‐ and...
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