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Excitotoxicity, depletion of energy metabolites, and ionic imbalance are the major factors involved in neurodegeneration mediated through excitatory amino acid transporter‐2 (EAAT‐2) dysfunction in ischemic insult. Recent studies have revealed that ceftriaxone expresses EAAT‐2 via nuclear transcription factor kappa‐B (NF‐kB) signaling pathway, stimulation of EAAT‐2 expression in the ischemic, and...
With the rapid emergence of drug resistant pathogens, it has become imperative to develop alternative medications as well as find new drug targets to overcome this crisis. Hence, this has become prime focus of several academic laboratories and pharmaceutical companies. Here, we report a computational protocol for identifying unique DNA sequence(s) in the pathogen which is absent in human and related...
Asymmetry (5′→3′) associated with each strand of the deoxyribonucleic acid (DNA) is inherent in the sugar‐phosphate backbone connectivity and is essential for replication and transcription. We note that this asymmetry is due to one single chemical bond (C3′ to C2′) in each nucleotide unit, and the absence of this bond results in directionally symmetric nucleic acids. We also discovered that creation...
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