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Light‐inducible regulation of cellular pathways and gene circuits in mammalian cells is a new frontier in mammalian genetic engineering. Optogenetic mammalian cell cultures, which are light‐sensitive engineered cells, utilize light to regulate gene expression and protein activity. As a low‐cost, tunable, and reversible input, light is highly adept at spatiotemporal and orthogonal regulation of cellular...
SARS‐CoV‐2 Spike is a key protein that mediates viral entry into cells and elicits antibody responses. Its importance in infection, diagnostics, and vaccinations has created a large demand for purified Spike for clinical and research applications. Spike is difficult to express, prompting modifications to the protein and expression platforms to improve yields. Alternatively, the Spike receptor‐binding...
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