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Background Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. Methods A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for...
Anti‐senescence therapies, such as drugs that specifically kill senescent cells, to stave off ageing are currently under investigation. While these interventions show promise, their potential pitfalls are discussed herein. We have shown that the mitochondria are essential for development of senescence and many of the associated phenotypes, including the often detrimental senescence‐associated secretory...
Targeting the SASP to combat ageing. In article number 1600235, Birch and Passos discuss potential senescence therapies in the fight against ageing. Senescence is characterised by the development of a secretory phenotype, whereby cells release pro‐inflammatory mediators; the so‐called senescence‐associated secretory phenotype (SASP). The SASP can impact on neighbouring cells, leading to further senescence...
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