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Elongator is a highly conserved multiprotein complex composed of six subunits (Elp1–6). Elongator has been associated with various cellular activities and has attracted clinical attention because of its role in certain neurodegenerative diseases. Here, we present the crystal structure of the Elp2 subunit revealing two seven-bladed WD40 β propellers, and show by structure-guided mutational analyses...
The protein 26S proteasome regulatory subunit p27 is one of the four chaperones that help in the assembly of the 19S regulatory particle (RP) of the 26S proteasome. In the present work, the N‐terminus of p27 (residues 1–128) from Mus musculus was cloned, expressed, purified and crystallized alone and in complex with the C‐terminal ATPase domain of Rpt5 (residues 173–442). The crystals of p27(1–128)...
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