Search results for: Zihui Xu

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article

The Impact of Mandatory Deleveraging on Corporate Tax Avoidance: Evidence from a Quasi‐experiment in China

Zihui Xu, Zifan Chen, Lixing Deng, Yan Yu

Australian Accounting Review > 32 > 3 > 352 - 366

Companies can use both debt and non‐debt tax shields to accomplish tax avoidance. Using a quasi‐experiment in China in which the government implemented deleveraging regulations in selected industries in 2015, this study provides novel evidence of the effect of mandatory deleveraging on corporate tax avoidance. The results show that implementing mandatory deleveraging leads to an increase in the degree...

article

Realistic simulation of hydraulic erosion on slope

Zhaoxi Yu, Gang Yang, Zihui Xu

Computer Animation and Virtual Worlds > 33 > 3-4 > n/a - n/a

Hydraulic erosion plays an important role in the formation of landform. Influenced by runoff, soil is destroyed, denuded, and transported to form a specific landform. The simulation of erosion can not only be used for the construction of realistic terrain, but also for evaluation in soil and water conservation, which has important research and application value. We construct a hydraulic erosion simulation...

article

Quercetin‐3‐O‐Glucuronide Alleviates Cognitive Deficit and Toxicity in Aβ_1‐42‐Induced AD‐Like Mice and SH‐SY5Y Cells

Mengdai Xu, Hao Huang, Xiaoxing Mo, Yalun Zhu, more

Molecular Nutrition & Food Research > 65 > 6 > n/a - n/a

Scope Alzheimer's disease (AD) is characterized by amyloid‐β (Aβ) related imbalance, Tau‐hyperphosphorylation, and neuroinflammation, in which Aβ and neuroinflammation can induce brain insulin resistance (IR). Gut microbiome disorder is correlated with inflammation in AD. As of yet, there are no effective treatments clinically. Thus, it is focused on the potential benefit of quercetin‐3‐O‐glucuronide...

article

The impact of type 2 diabetes and its management on the prognosis of patients with severe COVID‐19

Zihui Xu, Zhongjing Wang, Shuo Wang, Yingchun Ye, more

Journal of Diabetes > 12 > 12 > 909 - 918

Background Although type 2 diabetes mellitus (T2DM) patients with coronavirus disease 2019 (COVID‐19) develop a more severe condition compared to those without diabetes, the mechanisms for this are unknown. Moreover, the impact of treatment with antihyperglycemic drugs and glucocorticoids is unclear. Methods From 1584 COVID‐19 patients, 364 severe/critical COVID‐19 patients with clinical outcome...

article

Effects of Solvent Ratio on the Morphology, Growth, and Photoluminescence of Hexagonal Pyramidal β‐NaYF₄:Eu³⁺ Microrods

Tianxiang Zhao, Zihui Xu, Nan Chen, Jinpeng Liu, more

physica status solidi (a) > 217 > 15 > n/a - n/a

Hexagonal pyramidal β‐NaYF₄:Eu³⁺ are synthesized with a facile solvothermal method using the mixture of ethylene glycol and deionized water (DIW) as the reaction solvents. The solvent ratio has a strong effect on the morphology, growth, and photoluminescence (PL) properties of β‐NaYF₄:Eu³⁺. Both the particle size and the aspect ratio of length/diameter of the β‐NaYF₄:Eu³⁺ increase with the proportion...

article

Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus

Ji Liu, Kristie Conde, Peng Zhang, Varoth Lilascharoen, more

Neuron > 2017 > 96 > 4 > 897-909.e5

Glucagon-like Peptide 1 (GLP-1)-expressing neurons in the hindbrain send robust projections to the paraventricular nucleus of the hypothalamus (PVN), which is involved in the regulation of food intake. Here, we describe that stimulation of GLP-1 afferent fibers within the PVN is sufficient to suppress food intake independent of glutamate release. We also show that GLP-1 receptor (GLP-1R) activation...

article

Purα Repaired Expanded Hexanucleotide GGGGCC Repeat Noncoding RNA-Caused Neuronal Toxicity in Neuro-2a Cells

Jianying Shen, Yu Zhang, Shi Zhao, Hong Mao, more

Neurotoxicity Research > 2018 > 33 > 4 > 693-701

Expanded hexanucleotide GGGGCC repeat in a noncoding region of C9ORF72 is the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). However, its molecular pathogenesis remains unclear. In our previous study, the expanded GGGGCC repeats have been shown to be sufficient to cause neurodegeneration. In order to investigate the further role of expanded GGGGCC repeats...

article

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Marc P. Forrest, Hanwen Zhang, Winton Moy, Heather McGowan, more

Cell Stem Cell > 2017 > 21 > 3 > 305-318.e8

Most disease variants lie within noncoding genomic regions, making their functional interpretation challenging. Because chromatin openness strongly influences transcriptional activity, we hypothesized that cell-type-specific open chromatin regions (OCRs) might highlight disease-relevant noncoding sequences. To investigate, we mapped global OCRs in neurons differentiating from hiPSCs, a cellular model...

article

Cumulative effects of incorrect use of pesticides can lead to catastrophic outbreaks of pests

Xia Wang, Zihui Xu, Sanyi Tang, Robert A. Cheke

Chaos, Solitons & Fractals > 2017 > 100 > C > 7-19

Modeling external perturbations such as chemical control within each generation of discrete populations is challenging. Based on a method proposed in the literature, we have extended a discrete single species model with multiple instantaneous pesticide applications within each generation, and then discuss the existence and stability of the unique positive equilibrium. Further, the effects of the timing...

article

Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s disease

Liqi Shu, Wenjia Sun, Liping Li, Zihui Xu, more

BMC Genomics > 2016 > 17 > 1 > 1-11

Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder that leads to a decline in cognitive function. In AD, aggregates of amyloid β peptide precede the accumulation of neurofibrillary tangles, both of which are hallmarks of the disease. The great majority (>90 %) of the AD cases are not originated from genetic defects, therefore supporting the central roles of...

article

Admission glucose and in-hospital mortality in patients with acute myocardial infarction, with and without diabetes, from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis

Shi Zhao, Karthik Murugiah, Xi Li, Jing Li, more

The Lancet > 2015 > 386 > Supplement 1 > S43

The relation between blood glucose concentrations on hospital admission and in-hospital mortality in patients with acute myocardial infarction, with and without diabetes, has not been well characterised in Chinese patients. Using the China PEACE-Retrospective Acute Myocardial Infarction Study, we took a representative sample of patients with acute myocardial infarction from 2001, 2006, and 2011...

article

Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression

Bin Chen, Youzhi Zhang, Yang Wang, Jun Rao, more

The Journal of Steroid Biochemistry and Molecular Biology > 2014 > 143 > C > 11-18

Curcumin can inhibit cell proliferation of breast cancer, but the mechanism for this inhibition remains unclear. Over-expression of Flap endonuclease 1 (Fen1), a DNA repair-specific nuclease, is involved in the development of breast cancer. Nrf2 is a master regulator of cellular antioxidant defense systems. Curcumin can induce the expression of Nrf2 in both non-breast cancer cells and breast cancer...

article

Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain

Junjie U. Guo, Keith E. Szulwach, Yijing Su, Yujing Li, more

Frontiers in Biology > 2014 > 9 > 1 > 66-74

Mounting evidence points to critical roles for DNA modifications, including 5-methylcytosine (5mC) and its oxidized forms, in the development, plasticity and disorders of the mammalian nervous system. The novel DNA base 5- hydroxymethylcytosine (5hmC) is known to be capable of initiating passive or active DNA demethylation, but whether and how extensively 5hmC functions in shaping the post-mitotic...

article

Expression of coxsackievirus and adenovirus receptor (CAR)-Fc fusion protein in Pichia pastoris and characterization of its anti-coxsackievirus activity

Kebin Zhang, Hua Yu, Wei Xie, Zihui Xu, more

Journal of Biotechnology > 2013 > 164 > 4 > 461-468

Coxsackievirus and adenovirus receptors (CARs) are the common cellular receptors which mediate coxsackievirus or adenovirus infection. Receptor trap therapy, which uses soluble viral receptors to block the attachment and internalization of virus, has been developed for the inhibition of virus infection. In this study, we have constructed a pPIC3.5K/CAR-Fc expression plasmid for the economical and...

article

DNA Methylation in Neurodegenerative Disorders

Zihui Xu, Xuekun Li

Current Geriatrics Reports > 2012 > 1 > 4 > 199-205

Epigenetic mechanisms are essential in a host of biological processes and many different human diseases. Epigenetic modifications include DNA methylation, histone modification, non-coding RNA, and nucleosome positioning. In neuronal systems, extensive studies have revealed important regulatory roles of DNA methylation in brain function, from the embryonic stage through the process of aging. Here we...

article

Epigenetics-Based Therapeutics for Neurodegenerative Disorders

Zihui Xu, He Li, Peng Jin

Current Geriatrics Reports > 2012 > 1 > 4 > 229-236

Epigenetic regulation, such as DNA methylation and histone modification, is implicated in the aberrant changes in gene expression that occur during the progression of neurodegeneration. Many epigenetics-based drugs have been developed recently for the treatment of some neurodegenerative disorders, including Alzheimer’s, Parkinson’s, and Huntington’s diseases. Here we review recent studies that highlight...

article

Iron Homeostasis Regulates the Activity of the MicroRNA Pathway through Poly(C)-Binding Protein 2

Yujing Li, Li Lin, Zigang Li, Xuecheng Ye, more

Cell Metabolism > 2012 > 15 > 6 > 895-904

MicroRNAs (miRNAs) control gene expression by promoting degradation or repressing translation of target mRNAs. The components of the miRNA pathway are subject to diverse modifications that can modulate the abundance and function of miRNAs. Iron is essential for fundamental metabolic processes, and its homeostasis is tightly regulated. Here we identified iron chelators as a class of activator of the...

article

Role of noncoding RNAs in trinucleotide repeat neurodegenerative disorders

Huiping Tan, Zihui Xu, Peng Jin

Experimental Neurology > 2012 > 235 > 2 > 469-475

Increasingly complex networks of noncoding RNAs are being found to play important and diverse roles in the regulation of gene expression throughout the genome. Many lines of evidence are linking mutations and dysregulations of noncoding RNAs to a host of human diseases, and noncoding RNAs have been implicated in the molecular pathogenesis of some neurodegenerative disorders. The expansion of trinucleotide...

article

DNA Methylation in Neurodegenerative Disorders

Zihui Xu, Xuekun Li

Current Geriatrics Reports > 2012 > 1 > 4 > 199-205

article

Epigenetics-Based Therapeutics for Neurodegenerative Disorders

Zihui Xu, He Li, Peng Jin

Current Geriatrics Reports > 2012 > 1 > 4 > 229-236

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