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Mast cells acutely respond to allergens and other stimuli by releasing accumulated internal stores of inflammatory mediators and other secretory products by ''compound'' exocytosis involving massive granule-to-plasma membrane and granule-to-granule fusion. Our recent findings implicate the SNAP receptor (SNARE) protein SNAP-23 and secretory carrier membrane protein 2 (SCAMP2) as regulators of this...
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