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Objective
Defibrotide is a heterogenous mixture of polyanionic oligonucleotides currently approved for treatment of transplant‐associated venoocclusive disease. While defibrotide has a known role in limiting endothelial cell activation, some studies have also demonstrated anti‐leukocyte properties. In a recent study, we found that neutrophil extracellular traps (NETs) play a role in the thrombotic...
Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca 2+ mobilizing second messenger that has been identified. We have previously shown that NAADP analogs substituted at the 5-position of nicotinic acid were recognized by the sea urchin receptor at low concentration, whereas the 4- substituted analogs were not as potent. However, to date the structure–activity relationship...
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