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Objective
To investigate mechanisms underlying the capability of ADAM15 to transform FasL‐mediated death‐inducing signals into prosurvival activation of Src and focal adhesion kinase (FAK) in rheumatoid arthritis synovial fibroblasts (RASFs).
Methods
Caspase 3/7 activity and apoptosis rate were determined in RASFs and ADAM15‐transfected T/C28a4 cells upon Fas/CD95 triggering using enzyme assays...
ObjectiveTo study the contribution of ADAM15, a disintegrin metalloproteinase that is up‐regulated in the rheumatoid arthritis (RA) synovial membrane, to the characteristic resistance of RA synovial fibroblasts (RASFs) to apoptosis induction by genotoxic stress or stimulation with proapoptotic FasL, which is present at high concentrations in RA synovial fluid.
MethodsCaspase 3/7 activity and the...