Search results for: Wenjin Wang

Items from 1 to 20 out of 114 results

article

Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma

Jiaxiang Xie, Jingqi Zhang, Gan Xiong, Shengqi Ouyang, more

Background BRD4, belonging to the bromodomain extra‐terminal (BET) protein family, plays a unique role in tumor progression. However, the potential impact of BRD4 in ameloblastoma (AM) remains largely unknown. Herein, we aimed to assess the expression and functional role of BRD4 in AM. Methods The expression level of BRD4 was assessed by immunohistochemistry. The proliferation, migration, invasion,...

article

Synthesis of diacylglycerol‐terminated lipid–polymer conjugates: Application to cell surface modification

Wenjin Wang, Chuanjiang Zhou, Jiangping Guo, Yijia Yu, more

Journal of Applied Polymer Science > 141 > 26 > n/a - n/a

With the demand for the development of lipid–polymer conjugates (LPCs) for biomedical applications, the development of novel, rapid, and efficient methods for the synthesis of LPCs is of great significance. In this study, a novel Y‐type photoinitiator (Lipid‐PI) containing a diacylglycerol group was first synthesized, and then the polymerization of conjugated vinyl monomers such as oligoethylene glycol...

article

Prognostic value of tumor‐infiltrating immune cells in clinical early‐stage oral squamous cell carcinoma

Zhengxian Huang, Yanwen Lu, Wenjin Wang, Nan Xie, more

Journal of Oral Pathology & Medicine > 52 > 5 > 372 - 380

Background Tumor‐infiltrating immune cells (TIICs) are critical components of tumor immune microenvironment (TIME), which play crucial roles during tumor initiation, development, and progression. However, the prognostic value of TIICs is still not well documented in clinical early‐stage oral squamous cell carcinoma (OSCC). In this study, we aimed to assess the prognostic value of TIICs in clinical...

article

FOUR LIPS plays a role in meristemoid‐to‐GMC fate transition during stomatal development in Arabidopsis

Ping Li, Liang Chen, Xiaoli Gu, Mingfeng Zhao, more

The Plant Journal > 114 > 2 > 424 - 436

Meristemoids, which are stomatal precursor cells, exhibit self‐renewal and differentiation abilities. However, the only known core factor associated with meristemoid division termination and fate transition is the heterodimer formed by the basic helix–loop–helix proteins MUTE and SCREAMs (SCRMs). FOUR LIPS (FLP), a well‐known transcription factor that restricts guard mother cell (GMC) division, is...

article

Prognostic and clinicopathological significance of cytocapsular tubes in oral squamous cell carcinoma

Wenjin Wang, Nan Xie, Chen Yi, Ming Zhang, more

Journal of Oral Pathology & Medicine > 51 > 6 > 520 - 528

Background Cytocapsular tubes (CTs) provide membranous channels for cancer cells interconnection and multidirectional locomotion, which facilitate cancer cell transportation and metastasis. However, the clinicopathological significance of CTs has not been documented in oral squamous cell carcinoma (OSCC). Herein, we aimed to identify CTs and assess their clinicopathological significance in OSCC....

article

Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open‐label, long‐term extension study with up to 7.0 years of treatment

William J. Sandborn, Nervin Lawendy, Silvio Danese, Chinyu Su, more

Alimentary Pharmacology & Therapeutics > 55 > 4 > 464 - 478

Background Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. We present final data from OCTAVE Open, an open‐label, long‐term extension study. Aims The primary objective of OCTAVE Open was to assess the safety and tolerability of long‐term tofacitinib in patients with ulcerative colitis; evaluating efficacy was a secondary objective. Methods...

article

Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping

Ming Zhang, Yufei Li, Ruimin Feng, Zhongzheng Wang, more

Journal of Magnetic Resonance Imaging > 54 > 5 > 1585 - 1593

Background Quantitative susceptibility mapping (QSM) has been used to study the magnetic susceptibility properties of collagen fibers in articular cartilage; however, it is unclear whether QSM is sensitive to changes due to degradation caused by long‐distance running. It is clinically important to understand the link between long‐distance running and microstructural changes in knee cartilage. Purpose...

article

Video‐based actigraphy is an effective contact‐free method of assessing sleep in preterm infants

Xi Long, Javier Espina, Renée A. Otte, Wenjin Wang, more

Acta Paediatrica > 110 > 6 > 1815 - 1816

article

Machine learning of diffraction image patterns for accurate classification of cells modeled with different nuclear sizes

Jing Liu, Yaohui Xu, Wenjin Wang, Yuhua Wen, more

Journal of Biophotonics > 13 > 9 > n/a - n/a

Measurement of nuclear‐to‐cytoplasm (N:C) ratios plays an important role in detection of atypical and tumor cells. Yet, current clinical methods rely heavily on immunofluroescent staining and manual reading. To achieve the goal of rapid and label‐free cell classification, realistic optical cell models (OCMs) have been developed for simulation of diffraction imaging by single cells. A total of 1892...

article

Role of the arecoline/YAP1/BMP4 pathway in promoting endothelial‐mesenchymal transition in oral submucous fibrosis

Mianfeng Yao, Jiang Li, Shanshan Yuan, Xilei Zhu, more

Journal of Oral Pathology & Medicine > 49 > 4 > 305 - 310

Background Oral submucous fibrosis (OSF) is a potentially malignant lesion characterized by epithelial‐mesenchymal transition (EMT). Bone morphogenetic protein 4 (BMP4) promotes EMT in fibrotic diseases, but the underlying mechanisms and its potential role in OSF are unclear. This study investigates whether BMP4 plays a role in the pathogenesis of OSF and explores the underlying mechanisms. Methods...

article

Hypermethylation of microRNA‐149 activates SDF‐1/CXCR4 to promote osteogenic differentiation of mesenchymal stem cells

Guangjie Li, Jiangdong An, Xingwen Han, Xueliang Zhang, more

Journal of Cellular Physiology > 234 > 12 > 23485 - 23494

MicroRNAs (miRs) involve in osteogenic differentiation and osteogenic potential of mesenchymal stem cells (MSCs). Accordingly, the present study aimed to further uncover role miR‐149 plays in osteogenic differentiation of MSCs with the involvement of the stromal cell‐derived factor‐1 (SDF‐1)/CXC chemokine receptor‐4 (CXCR4) pathway. Initially, the osteogenic differentiation model was induced. Next,...

article

Fast-convolution multicarrier based frequency division multiple access

Yining Li, Wenjin Wang, Jiaheng Wang, Xiqi Gao

Science China Information Sciences > 2019 > 62 > 8 > 1-17

Fast-convolution multicarrier (FCMC), the asynchronous waveform with ultra-low sidelobe, has appeared to be a promising waveform technique for future wireless communications. In this paper, we investigate the filter bank optimization as well as receiver design including low-complexity channel estimator and equalizer for FCMC based frequency division multiple access (FDMA). Starting from the conventional...

article

Development and evaluation of realistic optical cell models for rapid and label‐free cell assay by diffraction imaging

Shuting Wang, Jing Liu, Jun Q. Lu, Wenjin Wang, more

Journal of Biophotonics > 12 > 4 > n/a - n/a

Methods for rapid and label‐free cell assay are highly desired in life science. Single‐shot diffraction imaging presents strong potentials to achieve this goal as evidenced by past experimental results using methods such as polarization diffraction imaging flow cytometry. We present here a platform of methods toward solving these problems and results of optical cell model (OCM) evaluations by calculations...

article

Solid phase microextraction of polycyclic aromatic hydrocarbons by using an etched stainless-steel fiber coated with a covalent organic framework

Xiumin Yang, Junmin Wang, Wenjin Wang, Shuaihua Zhang, more

Microchimica Acta > 2019 > 186 > 3 > 1-8

A new covalent organic framework (COF) was synthesized by the amide coupling between 1,3,5-tris(4-aminophenyl)benzene and trimesoyl chloride at room temperature. The COF was applied as a steel fiber coating for the solid phase microextraction of polycyclic aromatic hydrocarbons (PAHs) from water samples. The effect of extraction time, salt concentration, and extraction temperature on the efficiency...

article

Long‐term safety and tolerability of oral tofacitinib in patients with Crohn’s disease: results from a phase 2, open‐label, 48‐week extension study

Julián Panés, Geert R. D’Haens, Peter D. R. Higgins, Linda Mele, more

Alimentary Pharmacology & Therapeutics > 49 > 3 > 265 - 276

Background Tofacitinib is an oral, small molecule Janus kinase inhibitor that is being investigated for inflammatory bowel disease. Aims This 48‐week open‐label extension study primarily investigated long‐term safety of tofacitinib 5 and 10 mg b.d. and secondarily investigated efficacy as maintenance therapy in patients with Crohn's disease. Methods Patients who had completed the phase 2b maintenance...

article

From porous aromatic frameworks to nanoporous carbons: A novel solid-phase microextraction coating

Wenjin Wang, Zhi Li, Shuaihua Zhang, Xiumin Yang, more

Talanta > 2018 > 190 > C > 327-334

A novel nanoporous carbon (NPC) was constructed by utilizing the porous aromatic framework-6 (PAF-6) as both the template and carbon source along with KOH as a chemical activator. The newly-synthesized PAF-6 derived nanoporous carbon (PAF-6-NPC) was then employed as a solid-phase microextraction (SPME) fiber coating. Coupled with gas chromatography-flame ionization detection, the PAF-6-NPC fiber-based...

article

Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model

Suresh Mohan, Iván Coto Hernández, Wenjin Wang, Kaiyang Yin, more

The Laryngoscope > 128 > 11 > E386 - E392

Objective Use of cell culture and conventional in vivo mammalian models to assess nerve regeneration across guidance conduits is resource‐intensive. Herein we describe a high‐throughput platform utilizing transgenic mice for stain‐free axon visualization paired with rapid cryosection techniques for low‐cost screening of novel bioengineered nerve guidance conduit performance. Methods Interposition...

article

Nerve Repair With Fibrin Nerve Conduit and Modified Suture Placement

Wenjin Wang, Lucas Degrugillier, Mathias Tremp, Katharina Prautsch, more

The Anatomical Record > 301 > 10 > 1690 - 1696

Sutureless nerve repair has been regarded as a promising technique for nerve repair as the suture materials often results in neuroma formation and scar tissue that impede nerve regeneration. The aim of this study was to analyze the mechanical stability and morphological outcome of sutureless repair using fibrin glue conduit and an alternative approach of modified suture placement. Using rat sciatic...

article

Study on the Flexural Performance of Prestressed High Strength Concrete Pile

Zhijian Yang, Guochang Li, Wenjin Wang, Yajun Lv

KSCE Journal of Civil Engineering > 2018 > 22 > 10 > 4073-4082

Four prestressed high strength concrete (PHC) piles under low-cycle loading and two piles under monotonic flexural loading were tested to study the test phenomena, failure modes, hysteretic performance, ductility and bearing capacity. It was indicated that PHC piles failed suddenly and the bearing capacity decreased because of the tensile rupturing of prestressing tendons from the results, and the...

article

Preparation and mechanism analysis of an environment‐friendly maize seed coating agent

Defang Zeng, Zhao Fan, Xu Tian, Wenjin Wang, more

Journal of the Science of Food and Agriculture > 98 > 8 > 2889 - 2897

BACKGROUND Traditional seed coating agents often contain toxic ingredients, which contaminate the environment and threaten human health. This paper expounds a method of preparing a novel environment‐friendly seed coating agent for maize and researches its mechanism of action. The natural polysaccharide polymer, which is the main active ingredient of this environment‐friendly seed coating agent, has...

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INFONA - science communication portal

Search results for: Wenjin Wang

Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma

Synthesis of diacylglycerol‐terminated lipid–polymer conjugates: Application to cell surface modification

Prognostic value of tumor‐infiltrating immune cells in clinical early‐stage oral squamous cell carcinoma

FOUR LIPS plays a role in meristemoid‐to‐GMC fate transition during stomatal development in Arabidopsis

Prognostic and clinicopathological significance of cytocapsular tubes in oral squamous cell carcinoma

Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open‐label, long‐term extension study with up to 7.0 years of treatment

Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping

Video‐based actigraphy is an effective contact‐free method of assessing sleep in preterm infants

Machine learning of diffraction image patterns for accurate classification of cells modeled with different nuclear sizes

Role of the arecoline/YAP1/BMP4 pathway in promoting endothelial‐mesenchymal transition in oral submucous fibrosis

Hypermethylation of microRNA‐149 activates SDF‐1/CXCR4 to promote osteogenic differentiation of mesenchymal stem cells

Fast-convolution multicarrier based frequency division multiple access

Development and evaluation of realistic optical cell models for rapid and label‐free cell assay by diffraction imaging

Solid phase microextraction of polycyclic aromatic hydrocarbons by using an etched stainless-steel fiber coated with a covalent organic framework

Long‐term safety and tolerability of oral tofacitinib in patients with Crohn’s disease: results from a phase 2, open‐label, 48‐week extension study

From porous aromatic frameworks to nanoporous carbons: A novel solid-phase microextraction coating

Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model

Nerve Repair With Fibrin Nerve Conduit and Modified Suture Placement

Study on the Flexural Performance of Prestressed High Strength Concrete Pile

Preparation and mechanism analysis of an environment‐friendly maize seed coating agent

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