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IntroductionMechanisms and participating substances involved in the reduction of glomerular filtration (GFR) in contrast‐induced acute kidney injury (CI‐AKI) are still matter of debate. We hypothesized that diadenosine polyphosphates are released by the action of contrast media on tubular cells and may act on glomerular arterioles and reduce GFR.
MethodsFreshly isolated rat tubules were treated with...
AimGlomerular hyperfiltration is commonly observed in diabetics early after the onset of the disease and predicts the progression of nephropathy. Sustained hyperglycaemia is also closely associated with kidney hypertrophy and increased electrolyte and glucose reabsorption in the proximal tubule. In this study, we investigated the role of the increased tubular sodium/glucose cotransport for diabetes‐induced...
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