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BackgroundGlucagon‐like peptide‐2 (GLP‐2) is a pleiotropic hormone synthesized and secreted by the enteroendocrine ‘L’ cells able to exert intestine‐trophic and anti‐inflammatory effects. The antineoplastic drug cisplatin causes gastrointestinal alterations with clinical symptoms (nausea and vomiting) that greatly affect the therapy compliance. Experimentally, it has been reported that chronic cisplatin...
AimTo investigate the effects of endocannabinoids on non‐adrenergic, non‐cholinergic (NANC) relaxant responses in gastric strips from mice.
MethodsGastric longitudinal strips from the fundus region were mounted in organ baths for isometric recording.
ResultsIn carbachol‐precontracted strips, electrical field stimulation (EFS) elicited tetrodotoxin (TTX)‐sensitive fast nitrergic relaxant responses...
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