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Glaucoma is a degenerative disease that causes irreversible loss of vision and is characterized by retinal ganglion cell (RGC) loss. Others and we have demonstrated that chronic neuroinflammation mediated by reactive microglial cells plays a role in glaucomatous pathology. Exosomes are extracellular vesicles released by most cells, including microglia, that mediate intercellular communication. The...
Efficient electric activation and action potential propagation in the heart largely depends on gap junction (GJ) channels, formed by connexins (Cx) localized at the intercalated discs (IDs). Therefore, fine-tuning and maintenance of GJ in cardiomyocytes is essential for normal heart function. Several mechanisms have been implicated in the regulation of the amount of Cx43 at the plasma membrane. Results...
Purpose: This study aimed at elucidating the molecular mechanisms involved in the regulation of IL‐8 production by several oxysterols in retinal pigment epithelium (RPE) cells.
Methods: A human cell line from RPE (ARPE‐19) was used to test the role of cholesterol and several oxysterols (25‐OH, 7‐KC and 7β‐OH) in the expression and secretion of IL‐8. Expression of IL‐8 was assessed by real‐time PCR,...
Gap junctions (GJ) are specialized cell–cell contacts that provide direct intercellular communication (IC) between eukaryotic cells. Regulation of GJIC by degradation of Cx43 has been a matter of debate over the last two decades and both the proteasome and the lysosome have been implicated. However, the underlying mechanism and molecular players involved remain elusive. In this paper we demonstrate,...
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