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Precision medicine requires scalable bioinstrument for a personalized DNA sequencing, which can be label-free, cost-efficient, and high-throughput. This paper mainly presents three kinds of CMOS-based label-free sensors, including: i) a high-sensitivity ion-sensitive field-effect transistor (ISFET) sensor with pH-to-time-to-voltage conversion (pH-TVC); ii) a dual-mode sensor with image and chemical...
A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate...
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