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Annotating and understanding the function of proteins and other elements in a genome can be difficult in the absence of a well-studied and evolutionarily close relative. The causative agent of malaria, one of the oldest and most deadly global infectious diseases, is a good example of this problem. The burden of malaria is huge and there is a pressing need for new, more effective antimalarial strategies...
Malaria is one of the most deadly infectious diseases in the world. The malaria burden is characterized by 207 million cases and over 627,000 deaths annually. The consistent morbidity and mortality underscore an urgent need for the development of next-generation antimalarials. In this paper, we propose a network mining approach to uncover the protein-protein associations that are implicated in important...
Malaria is a serious infectious disease that affects 300–500 million people in the world. The proteins involved in heat shock response in the malaria parasite Plasmodium falciparum have long been considered as promising vaccine and drug targets. Our comprehensive network analysis reveals that about 103 heat shock proteins are associated with over 900 other proteins. They may play roles in a wide variety...
Plasmodium falciparum, the causative agent of human malaria, has a dynamic life cycle encompassing the mosquito vector and human hosts. Complex and atypical cell cycles are observed in malaria parasites. Cell cycle related proteins which play important roles in parasite life cycle, but distantly related to host proteins, may serve as desirable drug targets. In this study, based on the principle of...
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