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Purpose NADPH oxidase 5 (NOX5), the main isoform of NOX in spermatozoa, has been recognized as the main active generators of reactive oxygen species (ROS), including superoxide anion (O 2−. ) and hydrogen peroxide (H2O2). ROS have been shown to play important roles in many physiological and pathological conditions in spermatozoa. The present study aims to investigate the alterations of NOX5 protein...
Biochemical and physical modifications during the freeze–thaw process adversely influence the restoration of energy‐dependent sperm functions required for fertilization. Resveratrol, a phytoalexin, has been introduced to activate 5′ AMP‐activated protein kinase which is a cell energy sensor and a cell metabolism regulator. The cryoprotection of resveratrol on sperm cryoinjury via activation of AMP‐activated...
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