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Objective
To test whether systemic cytokine release is associated with central nervous system inflammatory responses and glial injury in immune effector cell‐associated neurotoxicity syndrome (ICANS) after chimeric antigen receptor (CAR)‐T cell therapy in children and young adults.
Methods
We performed a prospective cohort study of clinical manifestations as well as imaging, pathology, CSF, and...
Neurotoxicity is an important and common complication of chimeric antigen receptor-T cell therapies. Acute neurologic signs and/or symptoms occur in a significant proportion of patients treated with CD19-directed chimeric antigen receptor-T cells for B-cell malignancies. Clinical manifestations include headache, confusion, delirium, language disturbance, seizures and rarely, acute cerebral edema....
Some of the most common causes of blindness involve the degeneration of photoreceptors in the neural retina; photoreceptor replacement therapy might restore some vision in these individuals. Embryonic stem cells (ESCs) could, in principle, provide a source of photoreceptors to repair the retina. We have previously shown that retinal progenitors can be efficiently derived from human ESCs. We now show...
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