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Background
Programmed cell death‐1 (PD‐1) is a negative regulator of T‐cell responses. Expression of PD‐1 and its ligands PD‐L1 and PD‐L2 in chronic rhinosinusitis with nasal polyps (CRSwNP) is poorly studied.
Methods
Expression of PD‐1, PD‐L1, PD‐L2, TGF‐β, IL‐5, and IL‐10 mRNA was measured by real‐time quantitative PCR on tissue homogenates of patients with CRSwNP (n = 21) and healthy controls...
Summary Background Primary spontaneous pneumothorax (PSP) is a common medical condition in the emergency department. Clinically stable patients with large pneumothoraces usually undergo chest tube drainage. During the course of hospital stay, several chest X-rays are ordered at various time points. Because the number of chest X-rays during diagnosis and management of PSP can be quite high and...
BackgroundEdema represents a key feature of nasal polyp (NP) disease. Members of the vascular endothelial growth factor (VEGF) family may be involved, but the precise role of VEGF‐A, VEGF‐B, placental growth factor (PlGF), and their receptors VEGFR1 and VEGFR2 in NP edema formation remains elusive.
ObjectiveExploring the expression of VEGF family members and their receptors and their correlation...
To cite this article: Callebaut I, Spielberg L, Hox V, Bobic S, Jorissen M, Stalmans I, Scadding G, Ceuppens JL, Hellings PW. Conjunctival effects of a selective nasal pollen provocation. Allergy 2010; 65: 1173–1181.
AbstractBackground: Several clinical and experimental observations suggest that allergen deposition in the nose may partially be responsible for the induction of conjunctival symptoms...
To cite this article: Huvenne W, Callebaut I, Reekmans K, Hens G, Bobic S, Jorissen M, Bullens DMA, Ceuppens JL, Bachert C, Hellings PW. Staphylococcus aureus enterotoxin B augments granulocyte migration and survival via airway epithelial cell activation. Allergy 2010; 65: 1013–1020.
AbstractBackground: Staphylococcus aureus enterotoxin B (SEB) has recently been postulated to be involved in the pathology...
To cite this article: Buysschaert ID, Grulois V, Eloy P, Jorissen M, Rombaux P, Bertrand B, Collet S, Bobic S, Vlaminck S, Hellings PW, Lambrechts D. Genetic evidence for a role of IL33 in nasal polyposis. Allergy 2010; 65: 616–622.
AbstractBackground: Little is known about the genetic factors that contribute to nasal polyposis (NP). A genome‐wide association study identified 10 single nucleotide...
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