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Heterologous expression of many G‐protein coupled receptors (GPCRs) is a major bottleneck in drug discovery efforts for therapeutic development of the receptor. The goal of this study was to utilize domains from a well‐trafficked GPCR to aid in improving the trafficking of a related receptor. The adenosine A2a receptor (A2aR) shows exceptional expression and trafficking to the plasma membrane in yeast;...
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