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Proteolysis targeting chimera (PROTAC) has recently emerged as a promising strategy for inducing post‐translational knockdown of target proteins in disease treatment. The degradation of bromodomain‐containing protein 4 (BRD4), an essential nuclear protein for gene transcription, induced by PROTAC is proposed as an epigenetic approach to treat breast cancer. However, the poor membrane permeability...
Peroxynitrite (ONOO−) is a potent oxidant and nucleophile participating in a variety of pathophysiological processes as well as playing a major role in cancer therapy. However, the intracellular environment of solid tumors severely restricts the production of ONOO−, which leads to an unsatisfactory anticancer effect. Here, a tumor‐specific platform for ONOO− generation, prepared by linking a type...
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