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The development of tobacco use treatments that are effective for all smokers is critical to improving clinical and public health. The Multiphase Optimization Strategy (MOST) uses highly efficient factorial experiments to evaluate multiple intervention components for possible inclusion in an optimized tobacco use treatment. Factorial experiments permit analyses of the influence of patient characteristics...
Aims
To identify promising intervention components intended to help smokers to attain and maintain abstinence in their quit smoking attempts.
Design
A fully crossed, six‐factor randomized fractional factorial experiment.
Setting
Eleven primary care clinics in southern Wisconsin, USA.
Participants
A total of 637 adult smokers (55% women, 88% white) motivated to quit smoking who visited primary...
Background and aims
A chronic care strategy could potentially enhance the reach and effectiveness of smoking treatment by providing effective interventions for all smokers, including those who are initially unwilling to quit. This paper describes the conceptual bases of a National Cancer Institute‐funded research program designed to develop an optimized, comprehensive, chronic care smoking treatment...
Aims
To identify promising intervention components that help smokers attain and maintain abstinence during a quit attempt.
Design
A 2 × 2 × 2 × 2 × 2 randomized factorial experiment.
Setting
Eleven primary care clinics in Wisconsin, USA.
Participants
A total of 544 smokers (59% women, 86% white) recruited during primary care visits and motivated to quit.
Interventions
Five intervention components...
Aims
To screen promising intervention components designed to reduce smoking and promote abstinence in smokers initially unwilling to quit.
Design
A balanced, four‐factor, randomized factorial experiment.
Setting
Eleven primary care clinics in southern Wisconsin, USA.
Participants
A total of 517 adult smokers (63.4% women, 91.1% white) recruited during primary care visits who were willing to...
Rationale Tobacco withdrawal is a key factor in smoking relapse, but important questions about the withdrawal phenomenon remain. Objectives This research was intended to provide information about two core components of withdrawal (negative affect and craving): (1) how various withdrawal symptom profile dimensions (e.g., mean level, volatility, extreme values) differ between negative affect and craving;...
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