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Abnormal accumulation of β‐amyloid (Aβ) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress Aβ aggregate formation, thereby attenuating Aβ‐induced neurotoxicity. Here, the design of Aβ nanodepletors...
In article number 1910475, Elena A. Rozhkova, Chan Beum Park, Joonseok Lee, and co‐workers design Aβ nanodepletors constructed from ultralarge mesoporous silica nanostructures and anti‐Aβ single chain variable fragments, which effectively capture monomeric Aβ peptides, inhibit Aβ aggregate formation, and attenuate Aβ‐mediated cytotoxicity. The Aβ‐targeting and clearing capabilities of the Aβ nanodepletors...
Ferumoxytol capped anti PD‐L1 antibodies (aPD‐L1) loaded ultra‐large pore mesoporous silica nanoparticles (Fer‐ICB‐UPMSNPs) are delivered with image guidance after cabazitaxel (Cbz) chemotherapy for the treatment of prostate cancer. Sustained release of ICB from UPMSNP inhibits the immunosuppressive tumor microenvironment and activates tumor specific dendritic cells (DC). Activated antigen presenting...
Herein, ferumoxytol (Fer) capped antiprogrammed cell death‐ligand 1 (PD‐L1) antibodies (aPD‐L1) loaded ultralarge pore mesoporous silica nanoparticles (Fer‐ICB‐UPMSNPs) are formulated for a sequential magnetic resonance (MR) image guided local immunotherapy after cabazitaxel (Cbz) chemotherapy for the treatment of prostate cancer (PC). The highly porous framework of UPMSNP provides a large capacity...
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