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In the cell, tetrahydrofolate (H4folate) derivatives with a C1 unit are utilized in various ways, such as for the synthesis of amino acids and nucleic acids. While H4folate derivatives with the C1 unit are typically produced in the glycine cleavage system, Sphingobium sp. strain SYK‐6, which can utilize lignin‐derived aromatic compounds as a sole source of carbon and energy, lacks this pathway, probably...
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