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Introduction: Bak is a pro-apoptotic member of the Bcl-2 family, central regulators of the induction of apoptosis. We have previously shown that bak protein levels are decreased in some pancreatic cancer specimens which correlates with worse survival. The purpose of this study was twofold: 1) to determine mechanisms of bak transcriptional regulation, and 2) to determine whether restoration of bak...
Our report describes a 46-yr-old woman who presented with watery diarrhea in the presence of multiple endocrine neoplasia type I (MEN I) syndrome. Of various potential pancreatic endocrine hormones, only serum levels of pancreatic polypeptide were elevated. Radiologic imaging failed to identify a pancreatic tumor; her diarrhea was therefore managed with subcutaneous administration of somatostatin...
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