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A variety of bioreactor designs exist today as a result of previous efforts by engineers and researchers to construct optimal systems for a particular tissue engineering application. The primary purpose of any bioreactor is to provide a sterile cell culture environment that can be tightly controlled. A bioreactor can be as simple as a petri dish and as complex as an automatically controlled, cyclically...
The objective of this study was to investigate the effect of mechanical stimuli in combination with conditioned media (CM) on the osteogenic and chondrogenic differentiation of mesenchymal stem cells (MSCs). Two “opposing” groups were defined for the study. The first, designated the bone group, was formed by seeding MSCs onto porous poly(l-lactide-co-ε-caprolactone)/hydroxyapatite scaffolds. The second...
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