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Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties. The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic materials. Here we present a generic fluidic approach using convection and alternating flow to rapidly generate multi-centimeter...
The effectiveness of an imaging technique is often based on the ability to image quantitatively both morphological and physiological functions of the tissue. Here we present several ultrasound-based imaging techniques capable of visualizing both structural and functional properties of living tissue. Each imaging system utilizes custom-made, targeted nanoparticles developed to probe specific molecular...
In protein structure prediction, identifying the inter-residue contacts is a very important task to understand the mechanism of complicated protein folding and therefore to predict three-dimensional structures of proteins. So far, many methods were developed to predict inter-residue contacts. However, no special database consisting of detailed inter-residue contacts for each PDB protein chain has...
To investigated the activity ofSA-beta-GAL in rat hippocampus at different ages. Method: Hippocampus of 6, 18 and 24 month-age rats were observed by histochemical staining for SA-beta-GAL and cytochemical staining for SA-beta-GAL on prolong cultured hippocampal neurons. Results: SA-beta-GAL activity elevated in hippocampal pyramidal cells of CA3 region with advanced age. The upregulated SA-beta-GAL...
A novel biosensor working in both MOS capacitor and electric double-layer capacitor mode for real-time, label-free DNA detection is presented. The former mode measures density and polarity of charged biomolecules to be monitored, while the latter mode appears to reveal more of surface-molecule interactions and offers high sensitivity and easiness for diagnosis. A combined mode-utilization yields optimal...
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