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Viele Erkrankungen, wie Pneumonie, Trauma oder Sepsis, sind im Verlauf häufig mit der Entwicklung eines „acute respiratory distress syndrome“ (ARDS) vergesellschaftet. Aufgrund der assoziierten hohen Morbidität und Mortalität fokussiert sich eine Vielzahl von tierexperimentellen und klinischen Studien auf die Pathophysiologie und Therapie des ARDS. Störungen des Surfactant-Systems spielen bei der...
Objective This study assessed modulation of hypoxic pulmonary vasoconstriction (HPV) in isolated perfused rat lungs during sepsis induced by cecal ligation and perforation (CLP) at different times and its relationship to nitric oxide synthases (NOS). Design and setting Prospective controlled trial in a university research laboratory. Subjects 102 male Sprague-Dawley rats. Interventions Groups...
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