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The structure of the complex of the antibacterial drug trimethoprim with its target, the enzyme dihydrofolate reductase (DHFR) of Lactobacillus casei, was studied using multidimensional NMR spectroscopy. Aseries of 33 high-resolution structures of this complex in solution was calculated using the measured experimental parameters of the nuclear Overhauser effect, spin-spin coupling constants, and residual...