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Calcitonin gene-related peptide (CGRP) was examined for its effects on intracellular free Ca 2+ concentration ([Ca 2+ ] i ) in UMR 106 osteoblast-like cells. Cells loaded with the Ca 2+ dye FURA-2 dose-dependently responded to CGRP (1-100 nM) with transient two-fold increases in [Ca 2+ ] i . An intracellular source for this Ca ...
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