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Rationale. Nicotine can enhance attentional performance in humans, a property that may be of therapeutic utility. Objectives. To identify brain sites mediating nicotine-induced attentional enhancement. Methods. Nicotine (0, 1, 2, 4 and 8g) was injected bilaterally into the dorsal hippocampus and the prelimbic area of the prefrontal cortex, brain sites implicated in cognitive functions, of rats performing...
Pharmacological studies suggest that the discriminative stimulus (DS) produced by nicotine is mediated centrally. The aim of the present study was to identify neuroanatomical substrates that mediate the DS properties of nicotine. Specifically, the nucleus accumbens, a brain region known to mediate the DS effects of amphetamine and cocaine, was investigated using a two-lever operant drug discrimination...
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