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A hallmark in the pathophysiology of sepsis is the excessive release of endogenous and exogenous inflammatory mediators. Various blood purification techniques aiming at the removal of such mediators have been employed as adjunctive therapy in patients with sepsis. Renal-dose hemodialysis and hemofiltration with standard protocols and materials have proved ineffective. High-volume protocols and/or...
The transcription factor HIF-1α has been identified as a key regulator in the cellular and systemic response to hypoxia. Because hypoxia is frequently associated with acidosis, like in ischemia or tumour growth, we studied the impact of acidosis on the expression of the HIF-1α and HIF-2α proteins and that of the three HIF target genes carbonic anhydrase-9 (CA-9), glucose transporter-1 (Glut-1) and...
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