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BACKGROUNDProstatic inflammation is an important factor in development and progression of BPH/LUTS. This study was performed to characterize the normal development and vascular anatomy of the mouse prostate and then examine, for the first time, the effects of prostatic inflammation on the prostate vasculature.
METHODSAdult mice were perfused with India ink to visualize the prostatic vascular anatomy...
Human prostate adenocarcinoma is a multicentric disease with histological heterogeneity and variation in biological features. The present study showed that a cell with stem properties undergoing oncogenic transformation can produce prostate mouse lesions with varied histological phenotypes that resemble different grades of human prostate cancer. This powerful observation is consistent with the notion...
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