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The causative agent of leprosy is Mycobacterium leprae (M. leprae), which establishes infectious lesions in the skin. Leprosy is classified based on the clinical manifestation, the host’s immune response and skin symptoms. M. leprae is an intracellular pathogen that invades keratinocytes, macrophages, dendritic cells and Schwann cells and replicates within these cells. M. leprae-infected keratinocytes...
The kinase receptor-interacting protein (RIP) 1, a serine/threonine protein kinase, is a key signaling molecule for necrosis. The possible involvement of RIP1 in palmitate-induced macrophage death and its underlying molecular mechanism was investigated in this study.Cell viability was measured by an MTT reduction assay. The type of cell death was determined by staining with annexin V, propidium iodide...
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