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Minimal cut sets are a valuable tool for analyzing metabolic networks and for identifying optimal gene intervention strategies by eliminating unwanted metabolic functions and keeping desired functionality. Minimal cut sets rely on the concept of elementary flux modes which are sets of indivisible metabolic pathways under steady state condition. However, the computation of minimal cut sets is non-trivial,...
Background 13C metabolic flux analysis is one of the pertinent ways to compare two or more physiological states. From a more theoretical standpoint, the structural properties of metabolic networks can be analysed to explore feasible metabolic behaviours and to define the boundaries of steady state flux distributions. Elementary flux mode analysis is one of the most efficient methods for performing...
Many databases propose their own structure and format to provide data describing biological processes. This heterogeneity contributes to the difficulty of large systematic and automatic functional comparisons. To overcome these problems, we have used the Bio formal description scheme which allows multi-level representations of biological process information. Applied to the description of the tricarboxylic...
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